长链非编码RNA 牛磺酸上调基因1在胶质瘤中作用的研究进展

Research progress on role of long non-coding RNA taurine up-regulated gene 1 in glioma

摘要:

长链非编码RNA在癌症的发生发展过程中具有重要作用,其中牛磺酸上调基因1(TUG1)在不同癌症中具有不同的表达水平及作用机制,但在神经胶质瘤中的作用目前仍存在争议。TUG1既可以通过表观遗传学方式调控转录因子,也可以通过竞争性内源RNA方式调控转录后基因的表达。TUG1对胶质瘤的发生发展进行调控可能与肿瘤自我更新、细胞周期、细胞凋亡、染色质稳定、血肿瘤屏障及血管生成等有关。本文就TUG1在胶质瘤中的作用机制展开综述,总结目前TUG1在胶质瘤中作用的研究成果并预测其临床应用。

Abstract:

Long non-coding RNA plays an important role in the occurrence and development of cancer. Taurine up-regulated gene 1 (TUG1) has different expression levels and possesses different mechanisms of action in different cancers, but its role in glioma still remains controversial. TUG1 can regulate transcription factors by epigenetic means, and also regulate the expression of post-transcriptional genes through competitive endogenous RNA. TUG1 regulates the occurrence and development of glioma, which probably be associated with tumor self-renewal, cell cycle, apoptosis, chromatin stability, blood tumor barrier and angiogenesis. This article reviews the mechanism of TUG1 in gliomas, summarizes the current research results of TUG1 in glioma, and predicts its clinical application.