花生四烯酸细胞色素P450代谢途径在高血压中作用的研究进展

Role of arachidonic acid cytochrome P450 signal pathway in hypertension: a review on the research progress

摘要:

花生四烯酸是人体必须脂肪酸之一，其代谢产物具有较强生物学活性并在众多生理病理过程中发挥着重要调节作用。其在人体内主要通过环氧化酶、脂氧化酶、细胞色素P450（CYP）三大途径进行代谢。其中，越来越多的研究表明，CYP代谢途径中其关键基因CYP通过调控经ω-羟化酶、表氧化酶作用的下游产物20羟?二十烷四烯酸及表氧?二十碳三烯酸的质/量，从而影响高血压的发生发展，并且对其分子生物学机制及遗传学的研究亦成为当前的研究焦点。本文主要对CYP途径在高血压中的作用简要做一综述。

Abstract:

Arachidonic acid (AA) is one of the essential fatty acids for human beings, and its metabolites have strong biological activities and play important roles in regulating many physiological and pathological processes. AA is metabolized by three major pathways, including cyclooxygenases (COXs), lipoxygenases (LOXs) and cytochrome P450 (CYP). Recently, more and more evidences demonstrated that CYP pathway contributed to the pathogenesis of hypertension by regulating 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acid (EET), the downstream products of ω-hydroxylase and epoxygenase. The mechanisms of molecular biology and genetics of the pathway become a hot-spot in recent years. In this article, we reviewed the role of the CYP pathway in the hypertension.