无创血流储备分数的研究进展

Research progress in noninvasive fractional flow reserve

摘要:

传统的冠状动脉造影不能准确反映冠心病患者冠状动脉病变程度,血流储备分数(FFR)是诊断冠状动脉缺血病变的“金标准”,但需要使用压力导丝和血管扩张剂,会增加有创操作风险、手术时间和诊疗费用,限制了其在临床实践中的应用。近年来出现的无创FFR技术无需压力导丝和血管扩张剂,基于流体力学原理,利用冠状动脉CT或冠状动脉造影图像即可测定FFR,避免了有创FFR的不足,在临床研究中也表现出了良好的诊断价值,本文对无创FFR技术进行综述。

Abstract:

Conventional coronary angiography is unable to assess coronary artery lesions precisely in patients with coronary heart disease. Fractional flow reserve (FFR) is a “golden standard” for the diagnosis of coronary ischemic lesions. However, use of pressure guide wire and vasodilator will increase the risk for invasive operation, operation time and medical costs, which limits the application of FFR in clinical practice. In recent years, several noninvasive FFR techniques are developed based on fluid dynamics, which measure FFR with coronary CT or coronary angiography images, and avoid the need for wire manipulation and hyperaemic stimulus. And these techniques also show good diagnostic efficacy in clinical trials. This article reviews these noninvasive FFR techniques.