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中国人民解放军总医院老年心血管病研究所
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
景海芳,王雯,邱志新,郑建彪,王爱卿,刘东方,李宁.芪参还五胶囊对气血亏虚型帕金森病患者UPDRS评分及平衡能力的影响[J].中华老年多器官疾病杂志,2022,21(1):29~33
芪参还五胶囊对气血亏虚型帕金森病患者UPDRS评分及平衡能力的影响
Effect of Qishenhuanwu capsule on UPDRS scores and balance ability of Parkinson′s disease patients with Qi and Blood Deficiency
投稿时间:2021-04-12  
DOI:10.11915/j.issn.1671-5403.2022.01.007
中文关键词:  帕金森病;气血亏虚型;芪参还五胶囊;平衡功能
英文关键词:Parkinson′s disease; Qi and Blood Deficiency; Qishenhuanwu capsule; balance function This work was supported by the Project of Hebei Administration of Traditional Chinese Medicine
基金项目:河北省中医药管理局项目(2019296)
作者单位E-mail
景海芳 河北省沧州中西医结合医院脑病二科,河北 沧州 061001 853183279@qq.comeffect 
王雯 河北省沧州中西医结合医院脑病二科,河北 沧州 061001 853183279@qq.comeffect 
邱志新 河北省沧州中西医结合医院脑病二科,河北 沧州 061001 853183279@qq.comeffect 
郑建彪 河北省沧州中西医结合医院脑病二科,河北 沧州 061001 853183279@qq.comeffect 
王爱卿 河北省沧州中西医结合医院脑病二科,河北 沧州 061001 853183279@qq.comeffect 
刘东方 河北省沧州中西医结合医院脑病二科,河北 沧州 061001 853183279@qq.comeffect 
李宁 河北省沧州中西医结合医院脑病二科,河北 沧州 061001 853183279@qq.comeffect 
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中文摘要:
      目的 探讨芪参还五胶囊治疗气血亏虚型帕金森病(PD)患者的疗效及其对患者统一帕金森病评定量表(UPDRS)评分和平衡能力的影响。方法 选择2018年3月至2019年12月河北省沧州中西医结合医院住院治疗的气血亏虚型PD患者130例,按照药物治疗方式不同分为2组,每组患者65例。对照组行单纯多巴丝肼片治疗,芪参还五胶囊组在对照组基础上加用芪参还五胶囊治疗,2组均治疗3个月。比较治疗前和治疗后3个月2组治疗有效率、中医症候积分、UPDRS评分、Berg平衡量表(SSB)评分、PD生存质量调查表(PDQ-39)评分及不良反应情况。采用SPSS 23.0软件进行数据分析。根据数据类型,组间比较分别采用t检验及χ2检验。结果 治疗后3个月,芪参还五胶囊组总有效率为92.31%(60/65),高于对照组的80.00%(52/65),差异有统计学意义(P<0.05);2组组内中医症候积分、UPDRSⅡ评分、UPDRSⅢ评分、PDQ-36评分均下降,BBS评分升高(均P<0.05);芪参还五胶囊组中医症候积分、UPDRSⅡ评分、UPDRSⅢ评分均优于对照组(均P<0.05)。芪参还五胶囊组不良反应率为3.08%(2/65),对照组为7.69%(5/65),差异无统计学意义(P>0.05)。结论 芪参还五胶囊治疗气血亏虚型帕金森病病效果显著,不良反应小,可改善患者日常活动、运动功能及平衡功能,提高患者的生活质量。
英文摘要:
      Objective To investigate the efficacy of Qishenhuanwu capsule in treatment of Parkinson′s disease (PD) patients with Qi and Blood Deficiency and its effect on Unified Parkinson′s disease rating scale (UPDRS) scores and balance ability. Methods A total of 130 PD patients with Qi and Blood Deficiency treated in our hospital from March 2018 to December 2019 were recruited in this study, and were divided into control group (n=65, simple Basizide tablet) and Qishenhuanwu treatment group (n=65, Qishenhuanwu capsule plus Basizide tablet). All of the patients were treated for 3 months. The treatment efficiency, traditional Chinese medicine (TCM) symptom score, UPDRS score, Berg Balance Scale score, the Parkinson′s disease questionnaire-39 score, and adverse reactions were compared before and after treatment between 2 groups. SPSS statistics 23.0 was used for statistical analysis. Data comparison between two groups was perfomed using t test or χ2 test depending on data type. Results In 3 months after treatment, the total effective rate was 92.31% (60/65) in the Qishenhuanwu treatment group, significantly higher than that of the control group [80.00% (52/65), P<0.05]. After treatment, the TCM symptom score, UPDRSⅡ score, UPDRSⅢ score, and PDQ-36 score were all decreased, and the BBS score were increased in both groups (all P<0.05). The Qishenhuanwu group obtained better TCM symptom score, UPDRSⅡ score, and UPDRSⅢ score than the control group (all P<0.05). The adverse reaction rate was 3.08% (2/65) in the Qishenhuanwu group and 7.69% (5/65) in the control group, but there was no statistical difference between them (P>0.05). Conclusion Qishenhuanwu capsule shows significant effectiveness in treatment of PD patients with Qi and Blood Deficiency, with less adverse reactions, and can improve daily activities, motor function, balance function and the life quality of the patients.
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