miRNA在腹主动脉瘤中的研究进展

Research progress of miRNA in abdominal aortic aneurysm

摘要:

主动脉瘤是威胁人类健康的重要疾病,一般表现为主动脉病理性的扩张,以腹主动脉瘤最为常见。miRNA是一类单链非编码小RNA,广泛参与转录后基因表达的调控。随着近年研究的逐渐深入,miRNA已被视作腹主动脉瘤进展中的重要调控分子。理解miRNA在腹主动脉瘤发生发展中的调控机制,有助于疾病的早期诊断、靶向治疗及预后判断。

Abstract:

Aortic aneurysm(AA) is an important disease threatening human health. The general performance of AA is the pathological dilation of the aorta, and abdominal aortic aneurysm(AAA) is the most common type. miRNA is known as the single-stranded non-coding small RNA, which is widely involved in the regulation of post-transcriptional gene expression. With the deepening of research, miRNA has been regarded as a crucial regulatory molecule in the development of AAA. Understanding the regulatory role that miRNA plays in the development of AAA contributes to the early diagnosis and targeted therapy of AAA and facilitates the prognosis estimation.