脂蛋白(a)与糖尿病肾病相关性的研究进展

Progress on relationship between lipoprotein (a) and diabetic nephropathy

摘要:

大量证据表明,脂蛋白(a)与冠心病、脑卒中和钙化性主动脉瓣狭窄等心脑血管疾病密切相关。随着研究的深入,发现LP(a)与糖尿病肾病也有一定的相关性,可能在其发生发展、临床诊断及治疗上发挥一定的作用。本文就脂蛋白(a)的结构特点、遗传、代谢及与糖尿病肾病的相关性最新进展予以综述。

Abstract:

A lot of evidence indicates that lipoprotein(a) is related closely to coronary heart disease, stroke, calcified aortic valve disease and other cardio-cerebrovascular disease. With further research, the relationship between LP(a) and diabetic nephropathy (DN) is also discovered. LP(a) may play a certain role in the occurrence, development, clinical diagnosis and treatment of DN. In this article, we review the recent research progress in LP(a), in aspects of its structure properties, genetics, metabolism, and correlation with DN.