前列腺癌相关生物标志物的研究进展

Research progress in biologic markers for prostate cancer

摘要:

前列腺癌作为男性最为常见的癌症之一,严重威胁着男性的健康安全。前列腺癌在预测、诊断、预后方面都面临着诸多挑战。虽然用于指导前列腺癌的各种生物标志物具有一定的临床意义,但在单独使用时仍然显现出各自的局限性。精确诊断、防止过度活检、生物标志物联合诊断体系构建等仍然是当今前列腺癌检测的研究热点。本文分析了前列腺癌在检测中所面临的问题,并就临床上常用的前列腺癌生物标志物及其相关检测体系的研究进展进行综述。

Abstract:

As one of the most common cancers in men, prostate cancer seriously threatens their health and safety. There are many challenges of prostate cancer in prediction, diagnosis and prognosis. Although biomarkers for the prostate cancer have shown certain clinic significance, they still have limitations when used alone. Accurate diagnosis, prevention of excessive biopsies, and construction of a diagnostic system of combined biomarkers are still trending research topics in the detection of prostate cancer. Here we analyze the cha-llenges in the detection of prostate cancer and review the research progress in biomarkers and related detection systems of prostate cancer.