老年食管癌患者1591例心血管代谢性疾病分布特征及影响因素

Prevalence and risk factors of cardiometabolic diseases in 1591 elderly patients with esophageal cance

摘要:

通过分析老年食管癌患者心血管代谢性疾病(CMD)的分布特征,为其防治提供参考。方法 研究对象来自于2008年1月至2018年3月的住院病例,共纳入1591名老年食管癌患者。将糖尿病、高血压、缺血性心脏病、脑卒中作为主要的心血管代谢性疾病纳入研究。分析老年食管癌患者中CMD患病率、患病数量分布及人口学影响因素。采用SPSS 23.0统计软件进行数据分析。结果 1591例食管癌患者平均年龄为(71.84±5.00)岁,女性所占比例为25.14%(400/1591)。23.57%(375/1591)患有至少1种CMD,6.47%(103/1591)患≥2种CMD。CMD患病率有随年龄增加的趋势,但差别无统计学意义。糖尿病、高血压、缺血性心脏病、脑卒中的患病率分别为6.60%(105/1591)、17.10%(272/1591)、5.34%(85/1591)和1.76%(28/1591)。年龄增加、高体质量指数、非农民可能与食管癌共患CMD有关。结论 老年食管癌患者合并CMD应引起重视,建议加强多学科合作,特别关注高龄及超重的食管癌患者合并CMD的风险。

Abstract:

Objective To investigate the prevalence of cardiometabolic diseases (CMD) among elderly patients with esophageal cancer with a view to providing reference for their prevention and treatment. Methods The study enrolled 1591 elderly patients with esophageal cancer from January 2008 to March 2018. Analysis was made of the major CMD including diabetes, hypertension, ischemic heart disease and stroke. The prevalence of CMD, the number of concomitant CMD, and the risk factors of CMD in elderly patients with esophageal cancer were analyzed. SPSS statistics 23.0 was used for data analysis. Results Of the 1591 patients [average age(71.84±5.00) years; female 25.14%(400/1591)], 23.57%(375/1591) had at least one CMD, and 6.47%(103/1591) had two or more. The prevalence of CMD tended to increase with age without statistically significant difference. The prevalence was 6.60%(105/1591) for diabetes, 17.10%(272/1591) for hypertension, 5.34%(85/1591) for ischemic heart disease, and 1.76%(28/1591) for stroke. Increasing age, high body mass index, and non-farmer might be associated with the comorbidity of CMD and esophageal cancer. Conclusion More attention should be paid to elderly patients with esophageal cancer complicated with CMD. Strengthened multidisciplinary cooperation is recommendable, special attention being paid to the risk of CMD in elderly and overweight patients with esophageal cancer.