白介素-22在慢性代谢性疾病中的研究进展

Research progress of interleukin-22 in chronic metabolic diseases

摘要:

目的 白介素-22(IL-22)是IL-10细胞因子家族成员,可以由多种免疫细胞分泌。IL-22受体(IL-22R)主要在非造血源性内皮细胞和基质细胞中表达,IL-22通过与IL-22R结合在黏膜屏障防御、组织修复、上皮细胞存活和增殖中发挥重要作用。IL-22的表达与多种代谢性疾病密切相关,是近年来代谢领域研究的热点。本文就IL-22在脂肪性肝病、肥胖、糖尿病等慢性代谢性疾病中的研究进展进行综述。

Abstract:

Interleukin-22 (IL-22) , a member of the IL-10 cytokine family, is secreted by a variety of immune cells. Its receptor (IL-22R) is mainly expressed in non-hematopoietic endothelial cells and stromal cells. IL-22 plays important roles in mucosal barrier defense, tissue repair, epithelial cell survival and proliferation by binding to its receptor. The expression of IL-22 is closely associated with various metabolic diseases, and has become a hot topic in the field of metabolism in recent years. This article reviews the research progress of IL-22 in fatty liver disease, obesity, diabetes and other chronic metabolic diseases.