自拟天麻汤联合倍他司汀对老年良性阵发性位置性眩晕患者复位后残余头晕的疗效及生活质量的影响

Efficacy of self-made Tianma Decoction combined with betahistine on residual dizziness and quality of life in elderly patients with benign paroxysmal positional vertigo after reduction

摘要:

目的 探讨自拟天麻汤联合倍他司汀对老年良性阵发性位置性眩晕患者复位后残余头晕的疗效及生活质量的影响。方法 回顾性分析2016年1月至2018年1月于空军军医大学第一附属医院老年病科收治的200例老年良性阵发性位置性眩晕患者的临床资料,根据不同的治疗方法将其分为对照组和观察组,每组100例。对照组给予甲磺酸倍他司汀治疗,观察组在对照组基础上给予自拟天麻汤治疗。比较2组治疗后的疗效、中医证候积分、视觉模拟量表(VAS)评分及眩晕障碍量表(DHI)评分等。采用SPSS 19.0软件对数据进行分析。根据数据类型,组间比较分别采用χ²检验或t检验。结果 治疗后,观察组中医证候评分与VAS评分均低于对照组[(5.78±4.66)和(9.21±5.18)分,(1.52±0.69)和(3.41±0.88)分],差异均有统计学意义(均P<0.05)；观察组功能、情感及躯体评分均低于对照组[(10.08±2.54)和(15.72±2.80)分,(8.44±2.99)和(13.56±3.70)分,(7.26±1.34)和(12.49±2.11)分],差异均有统计学意义(均P<0.05)；观察组复发率及不良反应发生率均低于对照组[9.0%和39.0%,5.0%和14.0%],差异均有统计学意义(P<0.05)。结论 自拟天麻汤联合倍他司汀治疗老年良性阵发性位置性眩晕患者复位后残余头晕的疗效确切,可改善患者眩晕症状,提高其生活质量,且复发率较低,安全性较高。

Abstract:

Objective To investigate the efficacy of self-made Tianma Decoction combined with betahistine on residual dizziness and quality of life of the elderly patients with benign paroxysmal positional vertigo (BPPV) after reduction. Methods A retrospective analysis was made of the clinical data of 200 elderly BPPV patients who were treated in the First Affiliated Hospital of Air Force Medical University from January 2016 to January 2018. They were divided into control group and observation group according to different treatments, with 100 patients in each group. The control group was given betahistine mesylate, and the observation group was given self-made Tianma Decoction on the basis of the control group. After treatment, the two groups were compared for the efficacy, TCM syndrome score, visual analog scale (VAS) score and dizziness handicap inventory (DHI). SPSS statistics 19.0 was used for statistical analysis. Data comparison between groups was perfomed by using χ² test or t test depending on data type.Results After treatment, the TCM syndrome and VAS score score in the observation group were significantly lower than those in the control group [( 5.78±4.66) vs (9.21±5.18) points, (1.52±0.69) vs (3.41±0.88) points; P<0.05]. The observation group were lower than the control group in DHI scores of function [(10.08±2.54) vs (15.72±2.80)points], emotion [(8.44±2.99) vs (13.56±3.70)points], and physical body [(7.26±1.34) vs (12.49±2.11)points], the differences being statistically significant(all P<0.05). The recurrence rate and incidence of adverse reactions in the observation group were significantly lower than those in the control group [9.0%(9/100) vs 39.0%(39/100), 5.0%(5/100) vs 14.0%(14/100); all P <0.05]. Conclusion The self-made Tianma Decoction combined with betahistine is effective in treating residual dizziness in the elderly patients with benign paroxysmal positional vertigo, significantly alleviating the symptoms of vertigo, improving the quality of life, and reducing the recurrence rate with high safety.