脓毒症中线粒体的损伤及修复

Damage and repair of mitochondria in sepsis

摘要:

线粒体是细胞基础结构的重要组成部分,是细胞中制造能量的主要场所,并参与诸如细胞分化、细胞信息传递和细胞凋亡等过程。脓毒症中线粒体受到多途径的损害,包括缺氧损伤、呼吸链损伤、内分泌改变、线粒体渗透性转换、钙超载、线粒体DNA损伤等。近期许多学者通过研究脓毒症中线粒体修复的方法,期望为脓毒症患者寻找新的治疗方法。本文针对在脓毒症中线粒体的损伤机制及损伤后修复方法做一综述,为脓毒症的诊断和治疗提供理论基础和研究热点。

Abstract:

Mitochondria constitute an important part of cell infrastructure. They are the main places for energy production and participants in such processes as cell differentiation, cell information transmission and cell apoptosis. Mitochondria in sepsis are damaged in many ways, including hypoxia, damaged respiratory chain, endocrine changes, mitochondrial permeability transition, calcium overload, and mitochondrial DNA damage. Recently, many researchers have studied the methods for mitochondrial repair in sepsis, hoping to find new treatment methods for sepsis patients. This article reviews the mechanism of mitochondrial damage and repair methods in sepsis, providing theoretical basis and research hotspots for the diagnosis and treatment of sepsis.