microRNA在阿尔茨海默病中的研究进展

Progress in research of microRNA in Alzheimer′s disease

摘要:

随着阿尔茨海默病(AD)患病率的增加,明确AD发病机制成为医学界迫切需要解决的问题。microRNA (miRNA)参与了蛋白质合成的表观遗传调控,是一种与多种疾病(包括AD)状态相关的生物学标志。本文主要介绍了miRNA在AD中的研究进展,包括最近体内外实验中发现的其表达变化及调节通路,以及可保留神经系统miRNA分泌形态学的物质——外泌体。外泌体不仅可以提高miRNA检测率,还可通过炎症介质参与AD的损伤。

Abstract:

With the increasing prevalence of Alzheimer′s disease (AD), its pathogenesis has become an urgent problem in the medical community. microRNA involves in epigenetic regulation of protein synthesis and is a biological marker associated with a number of states, including AD. This paper mainly introduces progress made in the research of miRNA in AD in the respects of the newly discovered expression changes and regulatory pathways in vivo and in vitro and exosomes found recently to be able to preserve morphology of the miRNA secretion in the nervous system. The exosomes not only improve the detection rate of miRNA but also contribute to the damage in AD through inflammatory mediators.