巴曲酶联合高压氧治疗老年突发性耳聋的效果及相关影响因素

Efficacy and influencing factors of batroxobin combined with hyperbaric oxygen in treatment of sudden deafness in the elderly

摘要:

目的 分析巴曲酶联合高压氧治疗老年突发性耳聋(SSHL)的效果以及预后影响因素。方法 选取2017年6月至2019年6月我中心收治的老年SSHL患者209例,随机分为对照组104例和观察组105例。对照组予以巴曲酶治疗,观察组在对照组的基础上进行高压氧治疗。比较2组患者的临床疗效以及不良反应发生率,并分析预后影响因素。采用SPSS 19.0软件进行数据分析,两组间比较采用t/χ²检验,二元logistic回归模型分析影响患者预后的独立因素。结果 治疗后,观察组的总有效率为80.95%,显著高于对照组的68.26%(P<0.05)。2组患者的血流动力学和抗氧化酶活性明显优于治疗前(P<0.05),而观察组患者血流动力学和抗氧化酶活性的改善程度明显优于对照组(P<0.05)。对照组和观察组患者的不良反应发生率分别为34.62%和37.14%(P>0.05)。患者年龄、糖尿病、患病耳侧、发病至就诊时间、发病情况、伴有耳闷感、听力图类型等因素影响其预后。二元logistic回归分析结果表明听力图类型和发病至就诊时间为独立预后影响因素。结论 巴曲酶联合高压氧治疗老年SSHL的疗效确切,安全性高,其中听力图类型和发病至就诊时间可作为预测其治疗效果的独立预后因素。

Abstract:

Objective To investigate the efficacy of batroxobin combined with hyperbaric oxygen in treatment of sudden sensorine hearing loss (SSHL) in the elderly and the influencing factors on the prognosis. Methods A total of 209 elderly SSHL patients admitted to our medical center from June 2017 to June 2019 were recruited, and randomly divided into control group (n=104) and study group (n=105). The former group was treated with batroxobin, and the latter was treated with hyperbaric oxygen besides batroxobin. The clinical efficacy and incidence of adverse reactions were compared between the two groups, and the prognostic factors were analyzed. SPSS statistics 19.0 was used to perform the statistical analysis. Student′s t test or Chi-square test was employed for comparison between the groups. Binary logistic regression analysis was applied to analyze the independent factors affecting the prognosis. Results After treatment, the total effective rate was 80.95% in the study group, significantly higher than that (68.26%) of the control group(P<0.05). The hemodynamic parameters and antioxidant enzyme activity were significantly improved in both groups (P<0.05), and the improvements were more obvious in the study group (P<0.05). There was no statistical difference in the incidence of adverse reactions between the study group and control group (37.14% vs 34.62%, P>0.05). Age, diabetes, side of affected ear, interval from symptom onset to medical consultation, incidence, sense of ear fullness, and type of hearing loss curve were influencing factor on the prognosis. The results of binary logistic regression analysis showed that the type of hearing loss curve and the time from symptom onset to consultation were independent prognostic factors. Conclusion Batroxobin combined with hyperbaric oxygen is effective and safe in the treatment of elderly SSHL, and the type of hearing loss curve and the time from onset to consultation can be used as independent prognostic factors to predict its treatment effect.