氨甲环酸在脊柱外科围手术期中的应用

Perioperative use of tranexamic acid in spinal surgery

摘要:

氨甲环酸(TXA)是一种抗纤溶剂,其抗纤溶活性优于其他抗纤溶药物。TXA主要用于纤维蛋白溶解亢进所致的各种出血,在生殖、泌尿、神经、运动等多个系统学科已得到广泛应用。对于术中、术后血液丢失,除了术中自体血回输、控制性降压、低温麻醉等传统血液管理手段外,还可以采用术前、术后应用抗纤溶药物TXA。TXA因显著的止血效果、药物安全性,越来越受到外科医师的认可。

Abstract:

Tranexamic acid (TXA) is an anti-fibrinolytic agent with better antifibrinolytic activity than its counterparts. It is widely used for hemorrhages caused by fibrinolysis in reproductive, urinary, nervous, and athletic systems. For intraoperative and post-operative blood loss, preoperative and postoperative TXA can be used in addition to conventional blood management such as intraoperative autologous blood transfusion, controlled hypotension, and low temperature anesthesia. TXA is increasingly recognized by surgeons for its remarkable hemostasis and safety.