平均血小板体积与心房颤动相关性研究进展

Research progress on relationship between mean platelet volume and atrialfibrillation

摘要:

心房颤动(AF)的主要严重危害是局部血栓形成后脱落,并随血流循环到达全身各处血管,引发脑卒中和其他血栓栓塞事件。血小板活化是血栓形成机制中的重要组成部分,其中平均血小板体积(MPV)为血小板活性标志物之一,其检测手段较其他血小板活性标志物更简单、经济,且临床获取更广泛、便捷。国内外多项研究显示MPV与AF、AF的发生及AF相关卒中风险有关,本文拟对该领域相关研究进行综述,旨在为预防AF及其相关卒中提供理论依据。

Abstract:

The serious risk of atrial fibrillation (AF) is stroke and other thromboembolic events caused by local thrombosis that sheds off and travels in blood circulation to blood vessels throughout the body. Platelet activation is an important part of the mechanism of thrombosis, where mean platelet volume (MPV) serves as one of the markers of platelet activity. Its testing is simpler, more economical, more widely available, and more convenient than others. A number of studies at home and abroad have shown that MPV is related to AF itself, the occurrence of AF, and the risk of AF-related stroke. This review aimed to provide a more complete theoretical basis for the prevention of AF-related stroke.