同型半胱氨酸与冠状动脉钙化的相关性

Correlation between homocysteine and coronary artery calcification

摘要:

目的 探讨血浆同型半胱氨酸与冠状动脉钙化的关系。方法 329例接受冠状动脉CT血管成像检查的患者,根据冠状动脉CT血管成像结果及病变程度计算冠状动脉钙化积分并分组,测定同型半胱氨酸,分析同型半胱氨酸和冠状动脉钙化的关系。采用SPSS 23.0统计软件进行统计学分析,根据数据类型,分别采用t检验、方差分析、LSD检验、χ²检验对数据进行分析。结果 冠状动脉钙化组的同型半胱氨酸水平高于无钙化组(P＜0.05)。钙化组单支(n=53)、双支(n=63)及多支冠状动脉病变支数患者(n=58)同型半胱氨酸水平分别为(13.26±4.93)、(13.56±4.50)、(14.49±4.16)μmol/L,各组相比,差异无统计学意义(F=1.915, P=0.151)。不同冠状动脉钙化积分患者的同型半胱氨酸水平随冠状动脉钙化积分增加而升高,1~99分组、100~399分组、≥400分组分别为(12.94±4.64)、(14.29±4.50)、(14.29±4.50)μmol/L,差异有统计学意义(F=3.581, P=0.030)。冠状动脉钙化的发生与同型半胱氨酸有相关性(r=0.230,95%CI 0.150~0.349；P＜0.001)。结论 同型半胱氨酸水平与冠状动脉钙化发生及冠状动脉钙化程度有关,提示血浆同型半胱氨酸水平可能是冠状动脉钙化的生物标志物。

Abstract:

Objective To analyze the correlation between plasma homocysteine and coronary artery calcification. Methods A total of 329 patients undergoing coronary CT angiography were enrolled and grouped according to the coronary artery calcification score and the severity of coronary artery disease. The plasma homocysteine was measured, and an analysis was made of the correlation between homocysteine and coronary artery calcification. SPSS statistics 23.0 was used for statistical analysis, and depending on the type, data were analyzed using t test, analysis of variance, LSD test and χ² test. Results The concentration of homocysteine was higher in the calcification group than in the non-calcification group (P<0.05). In the calcificaton group, the homocysteine levels were (13.26±4.93)μmol/L in those with single lesion (n=53), (13.56±4.50)μmol/L in those with double lesions (n=63), and (14.49±4.16)μmol/L in those with multiple lesions (n=58), the difference being not statistically significant (F=1.915, P=0.151). Homocysteine concentrations increased with the increasing coronary artery calcification scores:(12.94±4.64)μmol/L in 1-99 group, (14.29±4.50)μmol/L in 100-399 group, (14.29±4.50)μmol/L in ≥400 group, the difference being statistically significant (F=3.581, P=0.030). The occurrence of coronary artery calcification was associated with the plasma homocysteine concentration (r=0.230,95%CI 0.150-0.349, P＜0.001). Conclusion Plasma homocysteine is related to the occurrence and severity of coronary artery calcification, suggesting that plasma homocysteine concentration may serve as a biomarker for coronary artery calcification.