老年糖尿病患者血糖波动与认知功能障碍关系的研究进展

Research progress on relationship between glucose fluctuation and cognitive impairment in elderly diabetic patients

摘要:

随着人们生活方式的转变及人口老龄化的影响,老年2型糖尿病(T2DM)的发病率不断增加。相较于无糖尿病的老年患者,合并糖尿病的老年患者认知功能下降的风险增加了1.5倍。目前已经有多项研究表明T2DM可以影响老年患者认知功能,关于持续高血糖与T2DM发生认知功能障碍的关系也逐渐引起重视。但有关老年T2DM患者血糖波动与认知功能障碍的关系及其机制研究尚不多见,本文就目前老年T2DM患者血糖波动与认知功能障碍发生的潜在机制进行全面综述。

Abstract:

An obvious increase is witnessed in the incidence of type 2 diabetes mellitus (T2DM) in the elderly with changes in people′s lifestyles and the aging of the population. Compared with non-diabetic elderly patients, the risk of cognitive decline increased by 1.5 times in the elderly T2DM patients. Studies have shown that T2DM can affect cognitive function in the elderly, and increasing attention has also been drawn to the relationship between persistent hyperglycemia and cognitive impairment in the elderly with T2DM. However, few studies have focused on the relationship between blood glucose fluctuation and cognitive impairment and its mechanism in those patients. This article reviews the potential mechanism of glucose fluctuation and cognitive impairment in elderly T2DM patients.