微小核糖核酸－375与肝细胞肝癌关系的研究进展

Research progress on relationship between micro ribonucleic acid-375 and hepatocellular carcinoma

摘要:

肝细胞肝癌(HCC)是全球最常见的恶性肿瘤之一,其早期症状隐匿,预后差,临床上对其早期诊断有一定的局限性。大量研究表明微小核糖核酸－375(miR-375)与HCC的发生发展有十分密切的关系,miR-375可通过靶向调节致癌基因信号通路影响HCC的发生或发展过程,是HCC早期诊断或预后的标志物。本文就近年miR-375与HCC研究的最新进展作一概述,为HCC的早期诊断、治疗及预后提供理论依据。

Abstract:

Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world with insidious early symptoms and poor prognosis. In clinical practice, there are some limitations in its early diagnosis. A wide array of studies have shown that micro ribonucleic acid-375 (miR-375) is closely related to the occurrence and development of HCC, exerting an effect by targeting oncogenic signaling pathways, thus serving as a marker of early diagnosis or prognosis of HCC. This article reviews the recent progress in the research on miRNA-375 and HCC, with a view of providing a theoretical basis for the early diagnosis, treatment and prognosis of HCC.