褪黑激素保护心肌缺血/再灌注损伤研究进展

Research progress in melatonin cardioprotection against ischaemia/reperfusion in jury

摘要:

褪黑激素是一类具有多种功能的激素,可通过结合特定受体,激活一系列复杂的信号通路,发挥心脏缺血/再灌注损伤的保护效应。本综述主要对褪黑激素受体、褪黑激素诱导心肌保护的可能作用机制、以及褪黑激素的药物应用和临床研究等进行简要概述。

Abstract:

Melatonin, a hormone with multiple functions, can activate a vast array of complex signaling pathways by binding specific receptors, thus protecting the heart against ischemia/reperfusion injury. This review summarizes on the melatonin receptors, the probable mechanism of melatonin-induced myocardial protection, and its therapeutic application and clinical research.