Abstract:Objective To investigate the correlation of interleukin-6 (IL-6) and prealbumin (PA) with heart failure with preserved ejection fraction (HF-PEF). Methods A total of 126 HF-PEF patients admitted in our department from June 2017 to May 2019 were recruited, and their clinical data were collected and retrospectively analyzed. According to the results of echocardiography, the patients were divided into decreased left ventricular diastolic function group and normal left ventricular diastolic function group, with 63 patients in each group. The levels of IL-6, PA, brain natriuretic peptide (BNP) and other biochemical indicators were compared between the 2 groups. Multivariate logistic regression analysis was used to identify the influencing factors of HF-PEF. SPSS statistics 22.0 was used for data analysis. Results The decreased left ventricular diastolic function group had significantly older age [(78.2±9.3) vs (70.3±8.9)years], higher body mass index [(25.2±3.4) vs (23.8±2.8)kg/m2], increased E/e′ [(13.4±5.5) vs (9.2±1.8)] and elevated levels of BNP [(115.0±128.9) vs (46.7±59.5)pg/ml] and IL-6 [(5.3±5.2) vs (3.3±3.4)pg/ml], but obviously lower levels of albumin [(38.9±3.8) vs (40.7±3.8)g/L] and PA [(21.5±4.6) vs (24.7±5.2)mg/dl] when compared with the normal left ventricular diastolic function group (P<0.05). Logistic regression analysis showed that age (OR=1.062,5%CI 1.007-1.119; P=0.026) and E/e′(OR=1.365,5%CI 1.127-1.653; P=0.002) were positively correlated with HF-PEF, while PA was negatively correlated with HF-PEF (OR=0.916,5%CI 0.842-0.997; P=0.043). Conclusion HF-PEF is related to age and PA level. Detection of PA may be helpful to early diagnosis of HF-PEF.