阻塞性睡眠呼吸暂停综合征患者骨代谢变化及机制研究进展

Research progress on bone metabolism and its mechanism in patients with obstructive sleep apnea syndrome

摘要:

阻塞性睡眠呼吸暂停综合征(OSAS)是临床上常见的睡眠障碍表现,同时也是患骨质疏松症的危险因素。OSAS患者的骨密度倾向于降低,但持不同观点的学者认为OSAS患者骨密度增加或不变。骨转换标志物包括骨吸收标志物和骨形成标志物,与骨密度相比,可快速反映骨代谢变化。OSAS患者存在长期慢性间歇性缺氧的病理生理基础,该过程可诱导骨代谢相关基因的表达发生改变,通过核转录因子-κB信号通路等机制影响骨代谢,但在临床上并未得到确切证实,目前相关机制尚不明确。

Abstract:

Obstructive sleep apnea syndrome(OSAS) is a common sleep disorder and a risk factor for osteoporosis. Bone mineral density tends to decrease in OSAS patients, but studies by different scholars have shown that bone density increases or remains unchanged. Bone turnover markers, including bone resorption markers and bone formation markers, reflect quickly changes in bone metabolism as compared with bone density. Long-term chronic intermittent hypoxia in OSAS patients induces alterations in the genes related to bone metabolism, affecting bone metabolism through signaling pathways such as changes in nuclear factor-κB. However, this has not been confirmed clinically and the related mechanism remains unknown.