心肌纤维化机制研究进展

Research progress on the mechanism of myocardial fibrosis

摘要:

心肌纤维化(MF)是指心肌中正常心肌细胞减少,心肌成纤维细胞(CFs)增生,Ⅰ型和Ⅲ型胶原蛋白比例升高,排列紊乱,细胞外基质(ECM)过度生成和沉积。MF是心室重构的主要病理表现,主要引起心肌舒张和收缩力下降,为多种心脏疾病的终末期表现,如高血压、冠心病、心律失常等。本文综述了MF机制的研究进展,以期为寻找有效靶点开发对应药物提供理论依据。

Abstract:

Myocardial fibrosis (MF) refers to the reduction of normal myocardial cells in myocardium, proliferation of cardiac fibroblasts (CFs) increased proportion of collagen protein type Ⅰ and type Ⅲ, disordered arrangement, and excessive production and deposition of extracellular matrix (ECM). MF, the major pathological manifestation of cardiac remodeling, mainly causes the decrease of myocardial diastolic and systolic force. It is the end-stage manifestation of many cardiac conditions, such as hypertension, coronary heart disease, and arrhythmia. This paper reviews the research progress on the mechanism of MF to provide theoretical basis for finding effective targets and developing corresponding drugs.