糖尿病性心肌病的发病机制及治疗方法研究进展

Progress in the research on pathogenesis and treatment of diabetic cardiomyopathy

摘要:

心血管疾病是2型糖尿病的主要并发症,约占2型糖尿病患者死亡人数的2/3。血糖异常、血脂异常、胰岛素抵抗、慢性低度炎症、氧化应激、内皮功能障碍、血管钙化和高凝状态等多种病理生理过程可加快2型糖尿病患者糖尿病心脏病的进展。糖尿病性心肌病是糖尿病心脏病中较为常见的一种,可导致心功能异常并最终进展为心力衰竭、心律失常,甚至猝死。本文综述了糖尿病性心肌病的发病机制,以及当前及未来潜在的治疗方法。

Abstract:

Cardiovascular diseases are major complications of type 2 diabetes, accounting for approximately two-thirds of deaths from type 2 diabetes. The research progression of diabetic heart disease in patients with type 2 diabetes is accelerated by a wide array of pathophysiological processes such as abnormal blood glucose, dyslipidemia, insulin resistance, chronic low-grade inflammation, oxidative stress, endothelial dysfunction, vascular calcification and hypercoagulability. Diabetic cardiomyopathy is one of the most common diabetic heart diseases that can lead to cardiac dysfunction and eventually to heart failure, arrhythmia, and even sudden death. This article reviews the pathogenesis of diabetic cardiomyopathy and available and potential treatment options.