长链非编码RNA调节痛风炎症信号通路的研究进展

Research progress of long non-coding RNAs in regulation of inflammatory signal pathways in gout

摘要:

长链非编码RNA(LncRNAs)是指无蛋白质编码功能、长度大于200个核苷酸的非编码RNA。随着基因测序及基因芯片的快速发展,越来越多的研究表明,LncRNAs可通过调节细胞免疫、表观遗传、基因转录及转录后水平调控基因表达,从而参与人体多种疾病的发病过程。近年来,随着生活习惯、饮食结构的改变,痛风患者日趋增多,有研究显示LncRNAs在痛风发病中尤其是在痛风相关炎症信号通路调控中发挥重要作用。本文就此部分研究进展进行综述,进一步揭示痛风发病机制,以期对痛风及其并发症的早期预防、治疗提供新方法。

Abstract:

Long non-coding RNAs(LncRNAs)are defined as a non-coding RNAs with no protein coding capability which are composed of over 200 nucleotides. With the rapid development of gene sequencing and gene chip, a growing number of studies have shown that LncRNAs are involved in the pathogenesis of many diseases in humans by regulating cellular immunity, epigenetics, gene transcription and post-transcriptional regulation for gene expression regulation. In recent years, with the change of living habits and dietary structure, the incidence of gout is on the rise. More studies have shown that LncRNAs play an important role in the pathogenesis of gout, especially in regulating inflammatory signaling pathways which are associated with gout. This article reviews the relationship of LncRNAs and inflammatory signaling pathways which were associated with gout, in order to further reveal the pathogenesis of gout and provide new methods for early prevention and treatment of gout and its complications.