线粒体功能障碍及炎症与衰老的相关关系

Correlation of mitochondrial dysfunction and inflammation with aging

摘要:

线粒体功能障碍和炎症是衰老及慢性退行性疾病的标志。线粒体功能障碍可能是引发衰老的始动因素,在衰老过程中,线粒体DNA发生不同程度的氧化损伤,导致细胞的能量代谢受损,细胞功能障碍,甚至死亡。同时衰老机体持续存在的低级别炎症反应可通过多种作用损害免疫系统的活化,而炎症代谢产物在调节免疫应答中的作用可为干预年龄相关疾病的病理过程提供依据。

Abstract:

Mitochondrial dysfunction and inflammation are signs of aging and chronic degenerative diseases. Mitochondrial dysfunction may be the initiating factor of aging in which process oxidative mitochondrial DNA damage occurs at varying degrees, resulting in impaired energy metabolism, cell dysfunction, and even death of cells. At the same time, the persistent low-level inflammatory response of aging organisms can impair the activation of the immune system through a variety of functions and the role of inflammatory metabolites in regulating immune response also can provide evidence for intervening the pathological process of age-related diseases.