老年慢性肾脏病合并肌少症的研究进展

Research progress in chronic kidney disease complicated with sarcopenia in the elderly

摘要:

肌少症是以骨骼肌质量、力量及功能降低为主要特征的退行性综合征。肌少症与衰老密切相关,但是,慢性肾脏病等疾病可以加速肌肉消耗,增加肌少症的发生率。慢性肾脏病患者易合并肌少症,其机制涉及炎症反应、蛋白质能量消耗、运动减少及维生素D缺乏等。早期识别肌少症的危险因素并对其进行干预,对于慢性肾脏病合并肌少症患者生活质量的改善至关重要。目前,干预措施主要有体育锻炼、营养补充及药物治疗等。本文就近年对老年慢性肾脏病合并肌少症的发病情况、机制及治疗的研究进展作一综述。

Abstract:

Sarcopenia is a degenerative syndrome characterized by reduced skeletal muscle mass, strength and function. It is closely related to aging, but some diseases like chronic kidney disease can accelerate muscle wasting and increase the incidence of sarcopenia. Those patients suffering from chronic kidney disease are prone to sarcopenia, and its mechanisms include inflammatory responses, protein energy wasting, reduced exercise and vitamin D deficiency. Early identification and intervention for sarcopenia is essential for improving the quality of life in the patients with chronic kidney disease complicated with sarcopenia. At present, the intervention measures mainly include physical exercise, nutrition supplement and drug treatment. This paper reviews the recent research progress in the pathogenesis, mechanism and treatment of chronic kidney disease complicated with sarcopenia.