三甲胺-N-氧化物致动脉粥样硬化机制研究进展

Research progress on mechanism of atherosclerosis induced by trimethylamine-N-oxide

摘要:

越来越多研究表明,肠道微生物群与动脉粥样硬化具有重要关联,食物中的卵磷脂、胆碱、肉碱等营养素被肠道微生物群代谢,其代谢产物三甲胺-N-氧化物(TMAO)可促进动脉粥样硬化。该机制尚未完全明确,但此观点为研究动脉粥样硬化及其他心脑血管疾病提供了新方向。本综述对近年来TMAO致动脉粥样硬化的相关机制作一汇总。

Abstract:

More and more studies have shown that the intestinal microbiota are significantly associated with atherosclerosis. The nutrients such as lecithin, choline and carnitine in food are metabolized by the intestinal microbiota, and their metabolite trimethylamine-N-oxide (TMAO) may contribute to atherosclerosis. Its mechanism is not fully understood, but such a view provides a new orientation for research on atherosclerosis and other cardiovascular and cerebrovascular diseases. In this review, we summarized research on the mechanisms of TMAO-induced atherosclerosis in recent years.