铁氧化应激与脑血管病的研究进展

Research progress in relation of iron oxidative stress and cerebrovascular diseases

摘要:

血清铁蛋白可作为炎症、贫血及肿瘤的标志性指标,是体内铁代谢及铁储存的重要指标。铁超载后,体内血清铁蛋白水平相应升高,过多的铁可以通过Fenton反应产生过多自由基,后者可通过氧化应激及脂质代谢、动脉粥样硬化等过程引起相关血管性疾病。本文对脑梗死、脑出血及脑白质疏松3种类型脑血管病中铁氧化应激的研究现状进行综述,以期从铁氧化应激的角度,寻求防治脑血管疾病的办法。

Abstract:

Serum ferritin, an important indicator of iron metabolism and iron storage in the body, can be used as a marker for inflammation, anemia and tumor. Iron overload results in increased serum ferritin, and excessive iron can generate excessive free radicals through Fenton reaction, which can contribute to occurrence of vascular diseases through oxidative stress, lipid metabolism and atherosclerosis. In this paper, we reviewed the status quo of the research on iron oxidative stress in cerebral infarction, cerebral hemorrhage and leukoaraiosis in a view to finding a way to prevent and treat cerebrovascular diseases in consideration of oxidative stress of iron.