老年慢性心力衰竭合并衰弱的研究进展

Progress in research on chronic heart failure and frailty in the elderly patients

摘要:

慢性心力衰竭(CHF)是一种严重的临床疾病,具有高死亡率及再住院率,是65岁以上老年人住院最常见的原因。衰弱是以生理储备下降、机体易损性增加、抗应激能力减退为主要特征的常见老年综合征。CHF合并衰弱具有较高的发病率,两者通过共同的病理生理机制对疾病的预后产生不良的影响。衰弱的识别在CHF人群中十分重要,实现对衰弱诊断标准及评估工具的统一能够增加对衰弱早期预防、识别及临床管理的能力。本文就老年CHF患者合并衰弱的发病情况、机制及评估的研究进展做一综述。

Abstract:

Chronic heart failure (CHF), a serious clinical condition with high mortality and rehospitalization rate, is the most common cause of hospitalization among the patients over 65 years old. Frailty is a common geriatric syndrome characterized by impaired physiologic reserve, increased vulnerability, and decreased resistance to stressors. The incidence of CHF in the frail people is high. CHF and frailty, through shared pathological pathways, adversely affected the prognosis. The identification of frailty in CHF population is of great importance, and a consensus on diagnostic criteria and models of assessment for frailty can enhance the capacity of its early prevention, identification and management. This paper reviews the recent progress in research on the prevalence, mechanism and assessment of CHF in the frail population.