胰岛素样生长因子结合蛋白-4作为动脉粥样硬化易损斑块标志物的研究进展

Research progress on insulin-like growth factor-binding protein-4 as a marker of vulnerable atherosclerotic plaque

摘要:

动脉易损斑块是导致主要不良心血管事件(MACEs)的重要危险因素,对易损斑块的早期准确评估及有效干预具有重要的临床意义。胰岛素样生长因子结合蛋白-4(IGFBP-4)是妊娠相关蛋白-A(PAPP-A)在易损斑块中水解的底物,可介导局部胰岛素样生长因子(IGF)释放,加速动脉粥样硬化斑块的进展,是易损斑块重要的生物标志物之一。易损斑块是急性冠脉综合征(ACS)的病理基础,是目前心血管领域的研究热点,本文综述了IGFBP-4在易损斑块发生发展中的作用及其判断易损斑块和预测MACEs的潜在作用。

Abstract:

Vulnerable plaque is one of the important risk factors for major adverse cardiovascular events, and its early detection and effective intervention are of great clinical significance. Insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) is a substrate of pregnancy-associated plasma protein-A (PAPP-A) in vulnerable plaques and mediates the release of IGF, which is likely to accelerate atherogenesis. Thus, IGFBP-4 serves as one of the important biomarkers of vulnerable plaque. Vulnerable plaque is the pathologenic basis of acute coronary syndrome and a much sought-after focus in cardiovascular field. In this article, we reviewed the role of IGFBP-4 in the development of vulnerable plaque and its potential in assessing plaque vulnerability and major adverse cardiovascular events.