老年性肾间质纤维化动物模型研究新进展

Recent progress in research with animal models for age-related renal interstitial fibrosis

摘要:

肾间质纤维化是老年慢性肾脏病的最终特征,也是导致肾功能衰竭的常见原因。为了解肾间质纤维化的病理生理学特征,使用动物模型至关重要。肾间质纤维化常见的动物模型包括:单侧输尿管梗阻模型、肾大部切除模型、缺血再灌注模型、环孢素A肾病模型、阿霉素肾病模型、马兜铃酸肾病模型等。我们对这些动物模型的研究进展进行汇总综述,以期为更好的开展基础研究奠定试验方法。

Abstract:

Interstitial fibrosis is the end-stage characteristic of chronic renal disease in the elderly and a common cause of renal failure. The use of animal models is essential for the understanding of the pathophysiology of renal interstitial fibrosis. The widely used animal models for this purpose include those with unilateral ureteral obstruction, subtotal nephrectomy, ischemia-reperfusion injury, cyclosporine A nephropathy, adriamycin nephropathy, stolochic acid nephropathy. These models were reviewed in this paper to provide a reference for the selection of a test method for better basic research.