柴胡舒肝散联合雷贝拉唑对老年消化性溃疡的疗效分析

Efficacy of Chaihu Shugan powder combined with rabeprazole in the treatment of peptic ulcer in the elderly

摘要:

目的 分析柴胡舒肝散联合雷贝拉唑对老年消化性溃疡的临床疗效。方法 选取垫江县人民医院消化内科老年消化性溃疡患者126例为研究对象,按照随机数字表法分成2组:对照组和观察组,每组63例。对照组患者给予以雷贝拉唑为主的三联治疗,观察组患者在此基础上辅以柴胡舒肝散治疗。连续治疗4周,对比2组患者的治疗效果、治疗前后白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、 表皮生长因子(EGF)、转化生长因子-α(TGF-α)水平变化以及不良反应的发生情况。采用SPSS 13.0软件进行数据处理。依据数据类型,组间比较分别采用t检验或χ²检验。结果 治疗后,观察组患者血清IL-6[(3.45±1.08) vs(4.28±1.76)μg/L]和TNF-α[(9.35±2.79) vs(10.64±3.05)μg/L]显著低于对照组,而EGF[(0.84±0.26) vs(0.72±0.22)ng/ml]和TGF-α[(7.55±1.93) vs(6.01±1.86)μg/ml]水平显著高于对照组,差异均具有统计学意义(P＜0.05)。治疗后对照组总有效率为87.30%,观察组总有效率为98.41%,组间比较差异有统计学意义(P＜0.05)。治疗后观察组患者幽门螺杆菌清除率(92.06% vs 71.43%)显著高于对照组(P<0.05)。治疗期间对照组不良反应发生率为15.87%,观察组不良反应发生率为14.28%,差异无统计学意义(P＞0.05)。结论 采用柴胡舒肝散联合雷贝拉唑治疗老年消化性溃疡的临床疗效确切,有助于降低机体炎症反应程度,提高生长因子水平,进而促进溃疡愈合。

Abstract:

Objective To analyze clinical efficacy of Chaihu Shugan powder combined with rabeprazole in the treatment of peptic ulcer in the elderly. Methods A total of 126 senile patients with peptic ulcer were selected for the study, who were treated in the Department of Gastroenterology, People′s Hospital of Dianjiang County. The patients were randomized into the control group and the observation group with 63 in each. The two groups were treated with rabeprazole-based triple therapy, with Chaihu Shugan Powder added into the therapeutic regimen for the observation group. After 4 weeks of continuous treatment, comparisons were made between the two groups in the aspects of efficacy, levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-α) before and after the treatment, and adverse reactions. Data was processed using SPSS statistics 13.0. Depending on data type, Student′s t test or χ² test was performed for comparison between groups. Results Compared with control group, the observation group had significantly lower level of serum IL-6 [(3.45±1.08) vs (4.28±1.76)μg/L] and TNF-α [(9.35±2.79) vs (10.64±3.05)μg/L] but significantly higher level of EGF [ (0.84±0.26) vs (0.72±0.22)ng/ml] and TGF-α [(7.55±1.93) vs (6.01±1.86)μg/ml], the differences being statistically significant (P<0.05). The total effective rate was 87.30% in the control group as against 98.41% in the observation group with significant difference (P<0.05). The clearance rate of Helicobacter pylori in the observation group was significantly higher than that in the control group (92.06% vs 71.43%; P<0.05). The incidence of adverse reactions was 15.87% in the control group and 14.28% in the observation group with no significant difference (P>0.05). Conclusion Chaihu Shugan powder combined with rabeprazole has definite efficacy in the treatment of peptic ulcer in the elderly, alleviating inflammation, increasing the level of growth factor, and promoting ulcer healing.