酒精性肝病肌肉减少症:发病机制与治疗进展

Pathogenesis and treatment for alcoholic liver disease with sarcopenia:a review

摘要:

酒精性肝病(ALD)是酒精滥用最常见的临床后果,包括酒精性脂肪肝、酒精性肝炎、肝纤维化和肝硬化。骨骼肌损失或肌肉减少症是酒精性肝病的主要并发症。肌肉减少症会对临床结局造成不利影响,包括生存期、生活质量、肝脏疾病的其他并发症及移植预后。本文就酒精性肝病肌肉减少症的发病机制和治疗进展进行综述,为进一步研究该病的发病机制和治疗方案提供依据。

Abstract:

Alcoholic liver diseases (ALD), the most common clinical consequences of alcohol abuse, include alcoholic fatty liver, alcoholic hepatitis, liver fibrosis and cirrhosis. Skeletal muscle loss or sarcopenia is a major complication of alcoholic liver diseases. Decreased muscle mass adversely affects clinical outcomes, including survival, quality of life, development of other complications, and post-transplant outcomes. In this review, we summarized progress made in pathogenesis of and treatment for alcoholic liver diseases with sarcopenia in the view of providing basis for further studies.