CXC趋化因子受体2及其配体在心血管疾病中的研究进展

Research progress on roles of CXC chemokine receptor 2 and its ligands in cardiovascular diseases

摘要:

CXC趋化因子受体2(CXCR₂)隶属趋化因子家族,其与配体的结合在心血管系统病理、生理各个阶段起重要作用,与高血压、心肌重塑、动脉硬化、腹主动脉瘤等重要疾病密切相关,已成为临床及基础研究的热点。本文就CXCR₂在心血管系统疾病中的研究进展作一综述。

Abstract:

C-X-C chemokine receptor 2 (CXCR₂) is a member of chemokine family, and has been much sought after both in preclinical and clinical research because its activation by its ligands plays an important role in the pathophysiology of a range of cardiovascular diseases, including hypertension, cardiac remodeling, atherosclerosis, and abdominal aortic aneurysm. This review focuses on the progress made in the studies about roles of CXCR₂ in cardiovascular diseases.