病态窦房结综合征的病因及药物治疗研究进展

Research progress on etiology and drug treatment of sick sinus syndrome

摘要:

病态窦房结综合征(SSS)是窦房结及其周围组织病变引起的一组临床综合征。该综合征的发生可能是由于多种原因使窦房结细胞及其周围组织受到影响进而导致起搏功能及传导功能障碍,主要表现为缓慢型心律失常。临床上除了应用电子起搏器治疗外,药物治疗研究较少。有报道称人参皂苷及二丁酰环磷腺苷钙能够调节心肌细胞代谢,改善窦房结功能,是药物治疗SSS的有效方法。本文拟对SSS发病机制、病因及相关药物治疗作一综述,以期为临床指导用药提供参考。

Abstract:

Sick sinus syndrome (SSS) is a group of clinical syndromes caused by lesions in sinoatrial node and its surrounding tissues. Its occurrence may be due to that a variety of reasons affect sinoatrial node cells and their surrounding tissues and thus lead to pacing and conduction dysfunction, which is mainly manifested as slow arrhythmia. In addition to the clinical treatment of electronic pacemakers, there are few studies on drug therapy. Studies show that ginsenosides and calcium dibutyryladenosine cyclophosphate can regulate myocardial cell metabolism and improve the function of the sinus node, and are effective drugs for SSS treatment. In this article, we reviewed the pathogenesis, etiology and drug treatment of SSS, so as to provide reference for clinical guidance of drug use.