Abstract:Objective To explore the different effects of 10% and 20% human serum albumin (HSA)solutions on the renal functions of the patients after cardiopulmonary bypass (CPB). Methods Totally 100 patients with hypoalbuminemia were enrolled in this study who received CPB from March 2016 to December 2016 in our department. The patients were randomly divided into 2 groups (20%HSA and 10%HSA, n=50). HAS were administered in all patients until the albumin (ALB) concentration was>35 g/L. The two groups were compared postoperatively in the aspects of relevant clinical indicators, the renal functions, the amount of HAS administered, drug usage, urine output, length of stay in the ICU, and postoperative hospital stay. SPSS statistics 21.0 was used for statistical analysis. Non-paired t test and Chi-square test was adopted for comparison between groups according to the data types, and univariate analysis of variance was used for intragroup comparison. Results ALB in the 2 groups decreased significantly on the day of operation compared with before operation, and in the first and second day after CPB, the level of ALB had some increases, but still lower than that before operation (P<0.05). The increase of serum creatinine (SCr) level in 2 groups was not obvious immediately after the operation compared with before operation, but in the first and second day, SCr were significantly higher (P<0.05). Blood urea nitrogen (BUN) in the 2 groups showed an upward trend in the day of operation, the first and second day after the operation, and BUN in the first and second day were significantly higher than that before operation(P<0.05); hemoglobin (Hb) level in the 2 groups in the day of operation were obviously lower than that before operation, and there were some different increases in the first and second day after operation, but still lower than that before operation(P<0.05). There was no significant difference at the same time point between the 2 groups before and after the operation, such as ALB, SCr, BUN, uric acid (UA) and Hb (P>0.05). A smaller amount of HSA were administered in the patients in 20%HSA group than those in 10%HSA group [(21.20±8.81) vs (30.00±10.41)g, P<0.01]. Besides, compared with 10%HSA group, the postoperative urine output on the second day was higher in 20%HSA group [(2.62±0.67) vs (2.13±0.82)ml/(kg·h), P<0.05]. No significant differences were found in other relevant indices between groups (P>0.05). Conclusion There is no significant difference between two HSA solutions(10% and 20%)in their effects on the renal function in the patients with hypoalbuminemia who had undergone CPB. However, administration of 20%HSA can significantly reduce the amount of albumin used to treat hypoproteinemia. In terms of increased postoperative urine output, 20%HSA is superior to 10%HSA.