The incidence of pancreatic disease is increasing year by year. Current treatments for these diseases are mainly control of symptoms,but there were not enough studies on pancreatic function recovery. Bone marrow mesenchymal stem cells (BMSCs)are a group of stem cells with high self-renewal capacity and multipotent stromal cells that can differentiate into a variety of cell types in bone marrow. The cells have special biological characteristics and tumor tropism. Great achievements have been obtained in vitro and in vivo for pancreatic diseases and diabetes mellitus, and these studies provide a theoretical and practical basis for the application of stem cell therapy. In the article, we reviewed the research progress of BMSCs in this field.