长链非编码RNA在癌症中的研究进展

Research progress of long non-coding RNA in cancer

摘要:

长链非编码RNA(lncRNA)在癌症中扮演重要的角色。基因组关联研究已经发现,大量的lncRNA与各种类型的癌症相关。lncRNA的表达和突变能够促进肿瘤的形成和转移。lncRNA可能具有肿瘤抑制和促进致癌作用。因为lncRNA的基因组表达具有多样性和特异性,所以,lncRNA被认定可以作为新的肿瘤分子标志物和治疗靶点。本文结合国内外最新报道,对lncRNA在癌症中的研究进展作一综述。

Abstract:

Long non-coding RNA (lncRNA) plays important roles in the pathogenesis of cancer. Increasing evidence in genome-wide association studies have demonstrated the implication of lncRNA with different types of cancer. Aberrant expression and mutation of lncRNA is associated with tumorigenesis, metastasis, and prognosis of cancer. lncRNA exerts effects on either tumor promotion or tumor suppression. Because of the diversity and specificity in genome expression, lncRNA is identified as new molecular markers and therapeutic targets for cancer. In this paper, the progress of lncRNA in cancer is reviewed with the latest reports at home and abroad.