不同肾小球滤过率评估公式在老年人中的适用性分析

Applicability analyses for glomerular filtration rate evaluation formula in the elderly

摘要:

肾小球滤过率(GFR)随年龄增长而下降,在老年人群中,GFR下降并不意味着其一定患有慢性肾脏病。GFR测定是全世界公认的评估肾功能最准确的方法。通过GFR评估公式如Cockcroft-Gault (CG)公式、肾脏病饮食调整研究(MDRD)公式和慢性肾脏病流行病合作研究(CKD-EPI)公式等来获得估算肾小球滤过率(eGFR)已被广泛应用于一般人群中。由于老年人肾脏会发生结构和生理性变化,通常用来评价肾功能的方法并不完全适于这一群体。因此,本文回顾了近年来相关文献资料,就老年人如何选用GFR评估公式作一系统综述。

Abstract:

Chronically reduced glomerular filtration rate (GFR) in old people does not always mean that they suffer from chronic kidney disease (CKD) since their GFR can just be reduced by aging. Measurement of GFR is recognized worldwide as the most accurate way of assessing renal function. GFR equations such as Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) are widely used to estimate GFR in the general population. However, because of the structural and physiological changes in the kidneys of the elderly, the common equations used to evaluate renal function are not entirely suitable for this population group. Therefore, we reviewed relevant literature in recent years, and made a systematic review on how to choose the glomerular filtration rate evaluation formula for the elderly.