阿尔茨海默病相关概念研究进展

Research progress of related concepts in Alzheimer disease

摘要:

随着人口老龄化的加剧,阿尔茨海默病(AD)患病率正逐年攀升,产生了巨大的社会和经济负担,并已成为一个重要的公共卫生问题。目前针对痴呆期患者的治疗效果欠佳,因此研究的热点正逐渐前移,由痴呆期治疗转向痴呆临床前期轻度认知损害的防治,以期对痴呆的发生发展进行较早预防,由此也衍生了许多定义。本文就AD认知损害的不同阶段(无症状性临床前阶段、轻度认知损害阶段和痴呆阶段)的相关概念进行了梳理,并作一较全面介绍,使临床医师能更好地理解AD认知损害各时期的概念。

Abstract:

With the development of population ageing, the incidence of Alzheimer disease (AD) is increasing year by year, and the disease has become an important problem of public health due to its heavy social and economic burden. Owing to the lack of effective treatment in dementia period, the current research hotspots have moved gradually forward, and studies have focused on the prevention and treatment in the pre-dementia phase — mild cognitive impairment. Thus, a great many definitions have generated. The article reviewed the related concepts of AD at different stages, including preclinical stage, mild cognitive impairment and dementia, in which the clinicians can achieve a comprehensive acknowledge on the common types of cognitive decline and on the stage of development.