Abstract:Objective To investigate the effect of functionally complete revascularization guided by fractional flow reserve (FFR)on the prognosis in the patients with non-ST segment elevation acute coronary syndrome(NSTE-ACS) and multi-vessel disease (MVD). Methods A total of 100 NSTE-ACS and MVD patients admitted in the Cardiological Department of the Hanzhong People’s Hospital from January to July 2016 were enrolled in this study. They were randomly divided into FFR group (undergoing functionally complete revascularization guided by FFR) and CAG group (receiving coronary angiography guided PCI treatment). The number of implanted stents, hospitalization expenses, and data of PCI were compared between the 2 groups.In the follow-up of 12 months,angina attacks, left ventricular ejection fraction(LVEF) and occurrence of major adverse cardiovascular events (MACEs) were also compared. SPSS statistics 19.0 was used for data processing. Student’s t test or Chi-square test were used to compare the differences between groups. Results Compared with the CAG group, the FFR group had less implanted stents [(2.0±1.5) vs (3.5±1.8), P<0.01] and lower hospitalization expenses [(43905±26242) vs (65884±20489)CNY, P=0.04], and better improved angina symptoms [(2.3±0.7) vs (4.1±0.5)times] and LVEF [(62.7±6.8)% vs (54.7±7.9)%]. The incidences of revascularization [4.1%(2/49) vs 17.7%(8/45), P=0.03] and MACEs [8.2%(4/49) vs 24.4%(11/45), P=0.03] were also significantly lower in the FFR group than in the CAG group. Conclusion Functionally complete revascularization guided by FFR significantly reduces the number of stents and hospitalization expenses, effectively improves the symptoms of angina attacks and heart function, and decreases the incidence of MACEs in 12 months after surgery. The approach shows obvious short-term benefit to the NSTE-ACS and MVD patients.