肺表面活性物质相关蛋白质D与哮喘的研究进展

Research advances in correlation between pulmonary surfactant-associated protein D and asthma

摘要:

哮喘是呼吸系统常见的慢性炎症性疾病。关于哮喘的生物学标记物种类较多,但目前尚未发现具有特异性的标记物。肺表面活性物质相关蛋白质D(SP-D)主要存在于肺内,但在肺以外的器官系统中也有少量表达。SP-D在机体防御及免疫监视中发挥重要作用,与多种肺部疾病密切相关。其中SP-D是哮喘发生、发展的重要参与者,可作为哮喘的生物学标记物。现就SP-D的功能及其在哮喘中的生物学标记物作用作一综述。

Abstract:

Asthma is a common chronic inflammatory disease of the respiratory system. There are many kinds of biomarkers for asthma, but no specific ones have been found yet. Pulmonary surfactant-associated protein D (SP-D) is mainly located in the lung, but also mildly expressed in the other organ systems. SP-D plays important roles in body defense and immune surveillance, and is closely related to many pulmonary diseases. The protein is essentially involved in the development and progression of asthma, and can be used as a biomarker of bronchial asthma. In this we article reviewed the function of SP-D and its role as biomarker in asthma.