重症哮喘表型及内型的研究进展

Progress in the research of phenotypes and endotypes of severe asthma

摘要:

支气管哮喘(简称哮喘)是由多种炎症细胞及细胞组分参与的气道慢性炎症性疾病,目前它被认为是一种异质性疾病,尤其重症哮喘。根据发病机制、临床表现及生物标志物等对重症哮喘患者进行精准分型及个体化治疗是目前研究的热点,可使哮喘患者获得最佳控制,本文对重症哮喘表型及内型进行了综述。

Abstract:

Bronchial asthma (also called asthma) is a chronic airway inflammatory disease, with involvement of a variety of inflammatory cells and cellular components. Nowadays, asthma, and severe asthma in particular, is increasingly recognized as a heterogeneous disease. Based on its pathogenesis, clinical manifestations, biomarkers, and so on, precise classification and individualized treatment have become current research hotspot for severe asthma patients. Only in this way, these patients can be well-controlled. The article reviewed the phenotypes and endotypes of severe asthma.