蒽环类抗肿瘤药诱发心肌病1例及文献复习

Anthracycline-induced cardiomyopathy in cancer therapy:one case report and literature review

摘要:

回顾性分析1例病情特殊的扩张性心肌病患者,65岁女性,之前无心脏病史。主要表现为胸闷、气短,相关检查提示扩张性心肌病,既往因乳腺癌接受蒽环类抗肿瘤药治疗。回顾之前发表的其他病例数据,总结蒽环类抗肿瘤药诱导心肌病的相关诊治经验,采用规范化、个体化治疗后患者症状缓解。因此,应用蒽环类抗肿瘤药治疗时应监测、防治由化疗药物导致的心脏毒性。若病变发展为慢性心脏毒性表现,则尽早应用改善心肌预后的药物。

Abstract:

We retrospectively analyzed a particular case of dilated cardiomyopathy, that is,a 65-year-old woman who had no history of heart disease mainly presenting chest tightness and shortness of breath. Related examinations suggested dilated cardiomyopathy, and the patient had ever received anthracycline drugs for breast cancer treatment. We reviewed related literatures and summarized the experience on diagnosis and treatment of anthracycline-induced cardiomyopathy. After standardized and individualized treatment, her symptoms were relieved. Therefore, we should monitor cardiac function during anthracyclines administration to prevent and treat cardiac toxicity caused by chemotherapy drugs. If the condition developes into chronic heart disease, the drugs to improve myocardial prognosis should be used as early as possible.