FGF23/Klotho在骨质疏松与血管钙化共病机制中的研究进展

Research progress of FGF23-Klotho axis in common pathogenesis of osteoporosis and vascular calcification

摘要:

骨质疏松和血管钙化均为伴随衰老而发病率增高的退行性疾病，受多种因素影响。两者的发生发展都与钙磷代谢密切相关。近年来，涌现出许多关于骨质疏松和动脉硬化共同发病机制的研究报道，成纤维细胞生长因子23（FGF23）/Klotho轴是热点之一，本文将对其在骨质疏松和血管钙化中的作用进行阐述。

Abstract:

Osteoporosis and vascular calcification are both degenerative diseases associated with aging, and affected by a variety of factors. The occurrence and development of the 2 diseases are closely related to calcium and phosphorus metabolism. Recently, there are many studies concerning their common pathogenesis. One of the hot spots is fibroblast growth factor-23 (FGF23)-Klotho axis. This article mainly elaborated its roles in the comorbidity of osteoporosis and vascular calcification.