硫氧还蛋白系统在骨质疏松症中的作用

Role of thioredoxin system in osteoporosis

摘要:

越来越多的研究表明氧化应激与骨质疏松症的发生密切相关，而硫氧还蛋白(Trx)系统其中一个重要作用就是参与调节细胞氧化还原状态以对抗氧化应激，其是由Trx、硫氧还蛋白还原酶(TrxR)和还原型辅酶Ⅱ(NADPH)以及硫氧还蛋白相互作用蛋白(TXNIP)组成的多功能小分子蛋白系统，因此在骨质疏松症的发生发展中扮有重要角色。本文综述了硫氧还蛋白系统和骨质疏松症之间的联系。

Abstract:

More and more studies indicate that oxidative stress is closely related to the occurrence of osteoporosis. But thioredoxin (Trx) system is a multifunctional small molecule protein system, consisting of Trx, thioredoxin reductase (TrxR), reduced coenzyme Ⅱ (NADPH) and thioredoxin interacting protein (TXNIP), and one of its important roles is involved in regulating cellular redox state against oxidative stress, and thus plays an important role in the occurrence and development of osteoporosis. This article reviewed the relationship between the thioredoxin system and osteoporosis.