白细胞介素8基因多态性与卵巢癌发生的关系

Association of interleukin 8 gene polymorphism with ovarian cancer

摘要:

【摘 要】 目的 研究白细胞介素8（IL-8）+781基因多态性与卵巢癌发生风险之间的关系。方法 筛选卵巢癌患者为病例组和年龄匹配的健康人为对照组，应用聚合酶链反应-限制性片段长度多态性分析检测IL-8+781基因多态性。结果 携带基因型TT发生卵巢癌的风险显著高于携带基因型CC（OR=3.385, 95%CI: 1.361～8.418; P=0.009），携带等位基因T发生卵巢癌风险显著高于等位基因C（OR=1.704, 95% CI: 1.122～2.590; P=0.013）。结论 IL-8+781基因多态性可能影响卵巢癌的发生。

Abstract:

Objective To investigate the relationship between polymorphism of IL-8+781 and risk of ovarian cancer. MethodsPatients with ovarian cancer and age-matched healthy people were enrolled in this study. The polymorphism of IL-8+781 was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The individuals with genotype TT had higher risk of ovarian cancer, compared with those with genotype CC (OR=3.385, 95%CI: 1.361-8.418, P=0.009). The individuals carrying allele T had higher risk of ovarian cancer than those carrying allele C (OR=1.704, 95%CI: 1.122-2.590, P=0.013). Conclusion IL-8+781 polymorphism may exert an effect on the occurrence of ovarian cancer.