半乳糖凝集素-3与心力衰竭相关性

Correlation of galectin-3 and heart failure

摘要:

心力衰竭（heart failure，HF）的病理生理基础是心室重构，而心室重构的基础是炎症和纤维化。近年研究发现，半乳糖凝集素-3在心脏调节机制中起重要作用，它的表达水平反映了心力衰竭的严重程度和分层，并可作为预测心力衰竭预后的生物学指标，但它在治疗心力衰竭方面的研究尚未成熟。本文综述了半乳糖凝集素-3与心力衰竭的相关研究，为临床医生提供了新的治疗思路。

Abstract:

The pathophysiological basis of heart failure (HF) is ventricular remodeling on the basis of inflammation and fibrosis. In recent years, evidence shows that galectin-3 plays an important role in the mechanism of cardiac regulation and has been recognized as a biological predictor for HF prognosis because its expression level reflects the severity and hierarchical of HF. However, its effect in the treatment of HF remains unclear. This article reviewed the studies on the correlation of galectin-3 and HF in order to provide new therapy ideas for clinicians.