有氧运动对轻中度阿尔茨海默病患者生活能力、认知功能和精神症状的影响

Effect of aerobic exercise on abilities in daily life, cognitive function and psychological symptoms in patients with mild to moderate Alzheimer’s disease

摘要:

目的 探讨有氧运动（快步行走）对轻中度阿尔茨海默病（AD）患者日常生活能力、认知功能和精神症状的影响。方法 选择 2013年6月至2014年12月在北京老年医院住院的78例轻中度AD患者，随机分为对照组（39例）和有氧运动组（39例）。在治疗前和治疗16周后均采用巴氏指数（BI）、简明智能精神状态检查量表（MMSE）和神经精神科问卷（NPI）进行评估。结果 治疗前两组患者的BI、MMSE评分、NPI评分差异均无统计学意义。接受16周快步行走干预后，有氧运动组患者的巴氏指数（BI）高于对照组、MMSE评分高于对照组、NPI评分低于对照组，差异均具有统计学意义（P＜0.05）。结论 有氧运动可提高轻中度AD患者的日常生活能力和记忆能力，改善患者的精神症状。

Abstract:

Objective To determine the effect of aerobic exercise(brisk walking) on cognitive function, abilities in daily life, and psychological symptoms in the patients with mild to moderate A1zheimer’s disease (AD). Methods A total of 78 patients with mild to moderate AD admitted to our hospital from June 2013 to December 2014 were recruited in this study. They were randomly divided into control group(conventional therapy, n＝39) and exercise group(conventional therapy＋outdoor brisk walking, n＝39). Barthel index (BI), Mini- Mental State Examination(MMSE) and Neuropsychiatric Inventory (NPI) were used to evaluate the efficacy of the two groups before and 16 weeks after treatment. Results Before treatment, the BI, MMSE scores and NPI scores had no significant difference between two groups. After 16 weeks’ brisk walking, the patients of the exercise group had significantly higher BI and MMSE scores and obviously lower NPI scores when compared with the control group(P＜0.05). Conclusion Aerobic exercise(brisk walking) improves the memory and abilities in daily life, and relieves the psychological symptoms in the patients with mild to moderate AD.