老年患者幽门螺杆菌感染与胃炎活动性相关性分析

Correlation of Helicobacter pylori infection and gastric mucosal inflammation in the elderly

摘要:

目的 探讨老年患者幽门螺杆菌（Hp）感染与胃炎活动性的相关性。方法 回顾性地分析2014年1月至2014年6月于北京老年医院接受胃镜及13C呼气试验检查的良性上消化道疾病患者278例，依据年龄分为年龄≥60岁（老年组）111例和年龄＜60岁（非老年组）167例，分别观察两组患者Hp感染情况及胃黏膜组织中性粒细胞浸润与Hp感染的关系。结果 老年组与非老年组比较，Hp感染率分别为27.0%（30/111）和36. 5%（61/167），差异无统计学意义（P＞0. 05）；中性粒细胞浸润率分别为18. 9%（21/111）和29. 3%（49/118），差异无统计学意义（P＞0. 05）；Hp阳性和Hp阴性患者中性粒细胞浸润分别为70. 3%（64/91）和3.2%（6/187），差异有统计学意义（P＜0.05）；Hp阳性患者老年组和非老年组中性粒细胞浸润分别为63. 3%（19/30）和73.8%（45/61），中性粒细胞浸分级（轻、中、重）分别为26. 3% vs 17. 8%，57. 9% vs 71. 1%，15. 8% vs 11. 1%，差异均无统计学意义（P＞0.05）。结论 胃黏膜急性炎症与Hp感染相关，急性炎症分级与感染年龄无关。

Abstract:

Objective To investigate the correlation of Helicobacter pylori(Hp) infection and gastric mucosal inflammation in the elderly. Methods A retrospective analysis was carried out on 278 patients with benign upper gastrointestinal diseases identified by endoscopy and 13C- UBT admitted in our hospital from January 2014 to June 2014. According to their ages, the patients were divided into the elderly group(age 60 or over years, n=111) and non- elderly group(age ＜60 years, n＝167). Hp infection, and its relationship with neutrophil infiltration in the gastric mucosa tissue were studied in the two groups. Results The Hp infection rate was 27.0%(30/111) and 36.5%(61/167) respectively(P＞0.05), and the rate of neutrophil infiltration was 18. 9%(21/111) and 29. 3%(49/118) respectively (P＞0.05) for the elderly group and non- elderly group. However, the Hp positive patients had significantly higher neutrophil infiltration rate(70.3%, 64/91) than the negative ones(3. 2%, 6/181; P＜0.05). In those positive to Hp, the neutrophil infiltration rate was 63.3%(19/30) and 73.8%(45/61) respectively for the patients from the elderly group and those from the non- elderly group, and the neutrophil infiltration severity(mild, moderate and severe) were 26. 3% vs 17. 8%, 57.9% vs 71.1%, and 15. 8% vs 11. 1% respectively between the two groups(P＞0.05). Conclusion Acute gastric mucosal inflammation is associated with Hp infection, and the inflammation severity is not related to the age of infected patients.